Immune mediators in the brain and peripheral tissues in autism spectrum disorder

Nature Reviews Neuroscience

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This article is a comprehensive detailed review of current research into the role of the immune system in the development of autistic spectrum disorder (ASD). There are a number of ASD associated genes and many encode components of the immune system. There are also a number of environmental risk factors for ASD many of which are mediated via the immune system. The authors end by raising the possibility of future treatment of some of the symptoms of ASD by targeting immune function.

Published by: Springer Nature

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Nature Reviews Neuroscience. Volume: 16, Pages 469–486 Year published: (2015) doi:10.1038/nrn3978 Published online 20 July 2015 Nature Reviews Neuroscience Myka L. Estes, A. Kimberley McAllister